Category Cancer

Researchers uncover the secret lives of hormone-binding proteins in cancer cells

Chimeric antigen receptor (CAR)-mediated therapy may slow down or even stop metastasis in several types of solid tumors, researchers at The University of Texas MD Anderson Cancer Center discovered in preclinical experiments.
Despite these approaches being FDA-approved, advanced-phase clinical trials involving these CAR-T cells have been hindered by the difficulty of matching high tumor dosage with sufficient tumor-specific T cell immunotherapy that can effectively eradicate cancer cells that have acquired resistance to the CAR-T cell therapy.
RBP5 is known to bind to an antigenic protein, a “signaling receptor” that acts as a gatekeeper of communication between cells.
A major hurdle in developing CAR-T cell therapy for T cell-positive cancer is that it lacks the DNA damaging property of conventional CAR-T cells.
This weakens the immunotherapy’s ability to target tumor-specific cell populations and makes it less effective in combination with the conventional immunotherapies used in the clinic.

Study reveals limits to measuring a child’s mental health

The emotional, cognitive and behavioral wellbeing of an infant can be closely linked to their parent’s mental health, new research at the University of Eastern Finland suggests. In the study, the researchers followed the progress of the offspring of mothers… Continue Reading →

Researchers point to immune cells’ role in regulating inflammatory response and memory

Until now, researchers thought that immune cells could suppress inflammatory reactions. Instead, they found that more immune cells increase inflammatory response and reduce inflammation – a finding that could offer a clue for future treatments of inflammatory diseases such as… Continue Reading →

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